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Publications

Papers, reviews, and preprints from the Lerner Lab, together with Talia Lerner’s earlier work.

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Preprints

2025

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking

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2025

Dopamine dips during unrewarded actions promote punishment-resistant reward seeking

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2025

Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum

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2025

Overexpression of alpha synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice

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2025

The role of mesolimbic dopamine circuitry in aversive signaling and opioid dependence

Branco P, Cox J, Wu Y, Morison, SL, Parker JG, Lerner TN, Martina M, Awatramani R, Surmeier DJ, Apkarian AV. Neuron. 2025 Sep 17:S0896-6273(25)00625-7. doi: 10.1016/j.neuron.2025.08.019. Online ahead of print.

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2025

Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning

Lopez GC, Van Camp LD, Kovaleski RF, Schaid MD, Sherathiya VN, Cox JM, and Lerner TN. Curr Biol. 2025 May 19;35(10):2433-2443.e5. doi: 10.1016/j.cub.2025.04.006.

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2025

How Dopamine Enables Learning from Aversion

Lopez GC and Lerner TN. Curr Opin Behav Sci. 2025 Feb;61:101476. doi: 10.1016/j.cobeha.2024.101476.

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2024

The Role of Dopamine in Training Automaticity

Lerner TN, Miller-Hansen AJ, and Ambrosi P. In: Vandaele, Y. (eds) Habits. Habits: Their Definition, Neurobiology, and Role in Addiction, 191-225. Springer, Cham.

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2024

Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson’s disease progression

Seiler JL, Zhuang X, Nelson AB, and Lerner TN. Experimental Neurology. 2024 Apr:374:114693.

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2024

Hidden variables in stress neurobiology research

Holloway AL and Lerner TN. Trends in Neurosciences. 2024 Jan;47(1):9-17.

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2023

Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms

Holloway AL, Schaid MD, and Lerner TN. Neuropsychopharmacology. 2023 Feb 21. doi: 10.1038/s41386-023-01551-1.

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2022

Striatonigrostriatal Circuit Architecture for Disinhibition of Dopamine Signaling

Ambrosi P and Lerner TN. Cell Reports. 2022 Aug 16;40(7):111228. doi:10.1016/j.celrep.2022.111228.

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2022

Intersectional mapping of multi-transmitter neurons and other cell types in the brain

Xu J, Jo A, DeVries RP, Deniz S, Cherian S, Sunmola I, Song X, Marshall JJ, Gruner KA, Daigle TL, Contractor A, Lerner TN, Zeng H, and Zhu Y. Cell Reports. 2022 2022 Jul 5;40(1):111036. doi: 10.1016/j.celrep.2022.111036.

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2022

Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive Behavior

Seiler JL, Cosme CV, Sherathiya VN, Schaid MD, Bianco JM, Bridgemohan AS, and Lerner TN. Current Biology. 2022 Mar 14;32(5):1175-1188.e5 doi: 10.1016/j.cub.2022.01.055.

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Raw data

2022

Editorial: Dopamine Neuron Diversity in Circuits and Diseases

Poulin JF, Lerner TN, and Howe MW. Frontiers in Neural Circuits. 2022 Mar 2;16:856716. doi: 10.3389/fncir.2022.856716.

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2021

GuPPy, a Python toolbox for the analysis of fiber photometry data

Sherathiya VN, Schaid MD, Seiler JL, Lopez GL, and Lerner TN. Scientific Reports. 2021 Dec 20; 24212. doi: 10.1038/s41598-021-03626-9.

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2021

Dopamine, Updated: Reward Prediction Error and Beyond

Lerner TN, Holloway AL, Seiler JL. Curr Opin Neurobiol. 2021 Apr;67:123-130. doi: 10.1016/j.conb.2020.10.012.

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2020

Parvalbumin+ and Npas1+ Pallidal Neurons Have Distinct Circuit Topology and Function

Pamukcu A, Cui Q, Xenias HS, Berceau BL, Augustine EC, Fan I, Chalasani S, Hantman AW, Lerner TN, Boca SM, Chan CS. J Neurosci. 2020 Oct 7;40(41):7855-7876. doi: 10.1523/JNEUROSCI.0361-20.2020.

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2020

Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning

Steinberg EE, Gore F, Heifets BD, Taylor MD, Norville ZC, Beier KT, Földy C, Lerner TN, Luo L, Deisseroth K, Malenka RC. Neuron. 2020 Jun 17;106(6):1026-1043.e9. doi: 10.1016/j.neuron.2020.03.016.

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2020

Interfacing Behavioral and Neural Circuit Models for Habit Formation

Lerner TN. J Neurosci Res. 2020 Jun;98(6):1031-1045. doi: 10.1002/jnr.24581.

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2019

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

Andalman AS, Burns VM, Lovett-Barron M, Broxton M, Poole B, Yang SJ, Grosenick L, Lerner TN, Chen R, Benster T, Mourrain P, Levoy M, Rajan K, Deisseroth K. Cell. 2019 May 2;177(4):970-985.e20. doi: 10.1016/j.cell.2019.02.037.

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2018

The effortless custody of automatism

Lerner TN. Science. 2018 Oct 12;362(6411):169. doi: 10.1126/science.aav1250.

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2018

A dLight-ful New View of Neuromodulation

Cosme CV, Palissery GK, Lerner TN. Trends Neurosci. 2018 Sep;41(9):566-568. doi: 10.1016/j.tins.2018.07.004.

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2016

Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making

Zalocusky KA, Ramakrishnan C, Lerner TN, Davidson TJ, Knutson B, Deisseroth K. Nature. 2016 Mar 31;531(7596):642-6. doi: 10.1038/nature17400.

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2016

Communication in Neural Circuits: Tools, Opportunities, and Challenges

Lerner TN, Ye L, Deisseroth K. Cell. 2016 Mar 10;164(6):1136-50. doi: 10.1016/j.cell.2016.02.027.

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2016

Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain

Kim CK, Yang SJ, Pichamoorthy N, Young NP, Kauvar I, Jennings JH, Lerner TN, Berndt A, Lee SY, Ramakrishnan C, Davidson TJ, Inoue M, Bito H, Deisseroth K. Nat Methods. 2016 Feb 15. doi: 10.1038/nmeth.3770.

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2015

Basomedial amygdala mediates top-down control of anxiety and fear

Adhikari A*, Lerner TN*, Finkelstein J*, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim SY, Lei A, Deisseroth K. Nature. 2015 Nov 12;527(7577):179-85. doi: 10.1038/nature15698. *co-first authors.

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2015

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

Lerner TN, Shilyansky C, Davidson TJ, Evans KE, Beier KT, Zalocusky KA, Crow AK, Malenka RC, Luo L, Tomer R, Deisseroth K. Cell. 2015 Jul 30;162(3):635-47. doi: 10.1016/j.cell.2015.07.014.

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2014

Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection

Mattis J, Brill J, Evans S, Lerner TN, Davidson TJ, Hyun M, Ramakrishnan C, Deisseroth K, Huguenard JR. J Neurosci. 2014 Aug 27;34(35):11769-80. doi: 10.1523/JNEUROSCI.5188-13.2014.

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2012

RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits

Lerner TN, Kreitzer AC. Neuron. 2012 Jan 26;73(2):347-59. doi: 10.1016/j.neuron.2011.11.015.

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2011

Neuromodulatory control of striatal plasticity and behavior

Lerner TN, Kreitzer AC. Curr Opin Neurobiol. 2011 Apr;21(2):322-7. doi: 10.1016/j.conb.2011.01.005.

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2010

Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists

Lerner TN, Horne EA, Stella N, Kreitzer AC. J Neurosci. 2010 Feb 10;30(6):2160-4. doi: 10.1523/JNEUROSCI.5844-09.2010.

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2009

Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway

Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S. ScientificWorldJournal. 2009 Nov 18;9:1321-44. doi: 10.1100/tsw.2009.143.

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